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ACSS2

Summary: This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameacyl-CoA synthetase short chain family member 2 OMIM IDMIM:605832 Ensembl IDEnsembl:ENSG00000131069 HGNC IDHGNC:HGNC:15814 PHARMGKB IDPA24429 Map Location20q11.22

GO terms in ACSS2

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005654	nucleoplasm
CC	IC	GO:0005737	cytoplasm
CC	TAS	GO:0005759	mitochondrial matrix
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0043231	intracellular membrane-bounded organelle

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Gene expression in normal tissue: ACSS2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACSS2

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Database	Pathway ID	Pathway Des.
smpdb	SMP00060	Pyruvate Metabolism
smpdb	SMP00196	Leigh Syndrome
smpdb	SMP00212	Pyruvate Dehydrogenase Complex Deficiency
smpdb	SMP00334	Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
smpdb	SMP00429	Disulfiram Action Pathway
smpdb	SMP00449	Ethanol Degradation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1
iGMDRD409	Saracatinib	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACSS2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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