Summary: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].

prion proteinMIM:176640Ensembl:ENSG00000171867HGNC:HGNC:9449PA3379620p13

GO terms in PRNP

Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0001933negative regulation of protein phosphorylation
BPNASGO:0006878cellular copper ion homeostasis
BPISSGO:0006979response to oxidative stress
BPIEAGO:0007050cell cycle arrest
BPISSGO:0007611learning or memory
BPTASGO:0007616long-term memory
BPTASGO:0010955negative regulation of protein processing
BPIMPGO:0031648protein destabilization
BPIEAGO:0032147activation of protein kinase activity
BPISSGO:0032689negative regulation of interferon-gamma production
BPISSGO:0032700negative regulation of interleukin-17 production
BPISSGO:0032703negative regulation of interleukin-2 production
BPIGIGO:0035584calcium-mediated signaling using intracellular calcium source
BPIEAGO:0035690cellular response to drug
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043086negative regulation of catalytic activity
BPISSGO:0043433negative regulation of DNA-binding transcription factor activity
BPIMPGO:0043525positive regulation of neuron apoptotic process
BPISSGO:0046007negative regulation of activated T cell proliferation
BPIEAGO:0046686response to cadmium ion
BPISSGO:0050730regulation of peptidyl-tyrosine phosphorylation
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPISSGO:0050860negative regulation of T cell receptor signaling pathway
BPIMPGO:0051260protein homooligomerization
BPIGIGO:0061098positive regulation of protein tyrosine kinase activity
BPISSGO:0070885negative regulation of calcineurin-NFAT signaling cascade
BPIDAGO:0071280cellular response to copper ion
BPISSGO:0090314positive regulation of protein targeting to membrane
BPISSGO:0090647modulation of age-related behavioral decline
BPTASGO:0097062dendritic spine maintenance
BPIEAGO:1900272negative regulation of long-term synaptic potentiation
BPISSGO:1900449regulation of glutamate receptor signaling pathway
BPISSGO:1901216positive regulation of neuron death
BPIEAGO:1901379regulation of potassium ion transmembrane transport
BPISSGO:1902430negative regulation of amyloid-beta formation
BPIGIGO:1902938regulation of intracellular calcium activated chloride channel activity
BPISSGO:1902951negative regulation of dendritic spine maintenance
BPISSGO:1902992negative regulation of amyloid precursor protein catabolic process
BPIEAGO:1903078positive regulation of protein localization to plasma membrane
BPISSGO:1904645response to amyloid-beta
BPIGIGO:1904646cellular response to amyloid-beta
BPISSGO:1905664regulation of calcium ion import across plasma membrane
BPISSGO:1990535neuron projection maintenance
CCISSGO:0005783endoplasmic reticulum
CCISSGO:0005794Golgi apparatus
CCIDAGO:0005886plasma membrane
CCISSGO:0005886plasma membrane
CCHDAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCISSGO:0014069postsynaptic density
CCTASGO:0014069postsynaptic density
CCIMPGO:0016234inclusion body
CCTASGO:0019898extrinsic component of membrane
CCNASGO:0031362anchored component of external side of plasma membrane
CCIDAGO:0031965nuclear membrane
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0045121membrane raft
CCIMPGO:0045121membrane raft
CCISSGO:0045121membrane raft
CCHDAGO:0070062extracellular exosome
MFIDAGO:0001540amyloid-beta binding
MFIPIGO:0001540amyloid-beta binding
MFISSGO:0001540amyloid-beta binding
MFTASGO:0001540amyloid-beta binding
MFISSGO:0002020protease binding
MFIDAGO:0005507copper ion binding
MFTASGO:0005507copper ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0005521lamin binding
MFISSGO:0005539glycosaminoglycan binding
MFIDAGO:0008017microtubule binding
MFIDAGO:0015631tubulin binding
MFIPIGO:0031802type 5 metabotropic glutamate receptor binding
MFISSGO:0031802type 5 metabotropic glutamate receptor binding
MFIDAGO:0031805type 8 metabotropic glutamate receptor binding
MFISSGO:0038023signaling receptor activity
MFIMPGO:0042802identical protein binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0043008ATP-dependent protein binding
MFIEAGO:0044325ion channel binding
MFIPIGO:0044877protein-containing complex binding
MFISSGO:0044877protein-containing complex binding
MFIEAGO:0051087chaperone binding
MFIEAGO:1903135cupric ion binding
MFIMPGO:1903136cuprous ion binding

Gene expression in normal tissue: PRNP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRNP

DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-419037NCAM1 interactions
reactomeR-HSA-422475Axon guidance
biocartaprionpathwayprion pathway
kegghsa04216Ferroptosis - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
pidglypican_1pathwayGlypican 1 network
wikipathwaysWP2806Human Complement System
wikipathwaysWP3286Copper homeostasis
wikipathwaysWP3995Prion disease pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRNP