AGPAT4
Summary: This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase 4 | MIM:614795 | Ensembl:ENSG00000026652 | HGNC:HGNC:20885 | PA134961047 | 6q26 |
GO terms in AGPAT4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | NAS | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | TAS | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016746 | transferase activity, transferring acyl groups |
| BP | IBA | GO:0006644 | phospholipid metabolic process |
| BP | TAS | GO:0006654 | phosphatidic acid biosynthetic process |
| BP | NAS | GO:0008654 | phospholipid biosynthetic process |
| BP | IEA | GO:0016024 | CDP-diacylglycerol biosynthetic process |
| CC | IBA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0012505 | endomembrane system |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: AGPAT4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AGPAT4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP325 | Triacylglyceride Synthesis |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| humancyc | PWY-5667 | CDP-diacylglycerol biosynthesis |
| humancyc | TRIGLSYN-PWY | triacylglycerol biosynthesis |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483166 | Synthesis of PA |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AGPAT4
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.