AGPAT4
Summary: This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:614795 Ensembl IDEnsembl:ENSG00000026652 HGNC IDHGNC:HGNC:20885 PHARMGKB IDPA134961047 Map Location6q26 | |||||
GO terms in AGPAT4
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | NAS | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | TAS | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016746 | transferase activity, transferring acyl groups |
| BP | IBA | GO:0006644 | phospholipid metabolic process |
Gene expression in normal tissue: AGPAT4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AGPAT4
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP325 | Triacylglyceride Synthesis |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| humancyc | PWY-5667 | CDP-diacylglycerol biosynthesis |
| humancyc | TRIGLSYN-PWY | triacylglycerol biosynthesis |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD491 | TAE-684 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AGPAT4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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