JPH2


Summary: Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
junctophilin 2MIM:605267Ensembl:ENSG00000149596HGNC:HGNC:14202PA2999920q13.12

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in JPH2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0051209release of sequestered calcium ion into cytosol
BPIEAGO:0055024regulation of cardiac muscle tissue development
BPIDAGO:0055074calcium ion homeostasis
BPTASGO:0060314regulation of ryanodine-sensitive calcium-release channel activity
BPIDAGO:0060316positive regulation of ryanodine-sensitive calcium-release channel activity
BPTASGO:0060402calcium ion transport into cytosol
CCIBAGO:0005783endoplasmic reticulum
CCIBAGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005886plasma membrane
CCIEAGO:0005886plasma membrane
CCTASGO:0014701junctional sarcoplasmic reticulum membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0016529sarcoplasmic reticulum
CCIEAGO:0030018Z disc
CCIBAGO:0030314junctional membrane complex
CCIEAGO:0030314junctional membrane complex
MFIDAGO:0001786phosphatidylserine binding
MFIPIGO:0005515protein binding
MFIDAGO:0005546phosphatidylinositol-4,5-bisphosphate binding
MFIDAGO:0005547phosphatidylinositol-3,4,5-trisphosphate binding
MFIDAGO:0010314phosphatidylinositol-5-phosphate binding
MFIBAGO:0015278calcium-release channel activity
MFIDAGO:0015278calcium-release channel activity
MFIDAGO:0032266phosphatidylinositol-3-phosphate binding
MFIDAGO:0070273phosphatidylinositol-4-phosphate binding
MFIDAGO:0070300phosphatidic acid binding
MFIDAGO:0080025phosphatidylinositol-3,5-bisphosphate binding

Gene expression in normal tissue: JPH2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in JPH2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47201

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JPH2

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