Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

ATPase phospholipid transporting 8B2MIM:605867Ensembl:ENSG00000143515HGNC:HGNC:13534PA251671q21.3

GO terms in ATP8B2

Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0007030Golgi organization
BPTASGO:0034220ion transmembrane transport
BPIBAGO:0045332phospholipid translocation
BPIEAGO:0045332phospholipid translocation
CCIEAGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005794Golgi apparatus
CCIDAGO:0005794Golgi apparatus
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
MFIEAGO:0000287magnesium ion binding
MFIBAGO:0004012phospholipid-translocating ATPase activity
MFTASGO:0004012phospholipid-translocating ATPase activity
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: ATP8B2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP8B2

DatabasePathway IDPathway Des.
wikipathwaysWP2857Mesodermal Commitment Pathway
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP8B2