RAD23B


Summary: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RAD23 homolog B, nucleotide excision repair proteinMIM:600062Ensembl:ENSG00000119318HGNC:HGNC:9813PA341739q31.2

Gene Categories:

DNA REPAIR

GO terms in RAD23B


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000502proteasome complex
CCIEAGO:0000502proteasome complex
CCTASGO:0005634nucleus
CCIBAGO:0005654nucleoplasm
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0071942XPC complex
BPIDAGO:0000715nucleotide-excision repair, DNA damage recognition
BPTASGO:0000715nucleotide-excision repair, DNA damage recognition
BPIDAGO:0006289nucleotide-excision repair
BPTASGO:0006294nucleotide-excision repair, preincision complex assembly
BPTASGO:0006457protein folding
BPIEAGO:0007283spermatogenesis
BPTASGO:0016579protein deubiquitination
BPIDAGO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIBAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIEAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIEAGO:0048568embryonic organ development
BPTASGO:0070911global genome nucleotide-excision repair
MFIEAGO:0003684damaged DNA binding
MFTASGO:0003697single-stranded DNA binding
MFIPIGO:0005515protein binding
MFIBAGO:0031593polyubiquitin modification-dependent protein binding
MFIDAGO:0031593polyubiquitin modification-dependent protein binding
MFIBAGO:0043130ubiquitin binding
MFIBAGO:0070628proteasome binding

Gene expression in normal tissue: RAD23B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAD23B


DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
kegghsa03420Nucleotide excision repair - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-532668N-glycan trimming in the ER and Calnexin/Calreticulin cycle
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689877Josephin domain DUBs
reactomeR-HSA-5696394DNA Damage Recognition in GG-NER
reactomeR-HSA-5696395Formation of Incision Complex in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73894DNA Repair

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD42Vorinostat1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAD23B

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