RAD23B
Summary: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAD23 homolog B, nucleotide excision repair protein | MIM:600062 | Ensembl:ENSG00000119318 | HGNC:HGNC:9813 | PA34173 | 9q31.2 |
Gene Categories:
DNA REPAIRGO terms in RAD23B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000502 | proteasome complex |
| CC | IEA | GO:0000502 | proteasome complex |
| CC | TAS | GO:0005634 | nucleus |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0071942 | XPC complex |
| BP | IDA | GO:0000715 | nucleotide-excision repair, DNA damage recognition |
| BP | TAS | GO:0000715 | nucleotide-excision repair, DNA damage recognition |
| BP | IDA | GO:0006289 | nucleotide-excision repair |
| BP | TAS | GO:0006294 | nucleotide-excision repair, preincision complex assembly |
| BP | TAS | GO:0006457 | protein folding |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0048568 | embryonic organ development |
| BP | TAS | GO:0070911 | global genome nucleotide-excision repair |
| MF | IEA | GO:0003684 | damaged DNA binding |
| MF | TAS | GO:0003697 | single-stranded DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031593 | polyubiquitin modification-dependent protein binding |
| MF | IDA | GO:0031593 | polyubiquitin modification-dependent protein binding |
| MF | IBA | GO:0043130 | ubiquitin binding |
| MF | IBA | GO:0070628 | proteasome binding |
Gene expression in normal tissue: RAD23B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAD23B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| kegg | hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689877 | Josephin domain DUBs |
| reactome | R-HSA-5696394 | DNA Damage Recognition in GG-NER |
| reactome | R-HSA-5696395 | Formation of Incision Complex in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73894 | DNA Repair |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAD23B
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