Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016].

RAD51 paralog BMIM:602948Ensembl:ENSG00000182185HGNC:HGNC:9822PA3417814q24.1

GO terms in RAD51B

Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000707meiotic DNA recombinase assembly
BPIMPGO:0000724double-strand break repair via homologous recombination
BPTASGO:0006281DNA repair
BPTASGO:0006310DNA recombination
BPIBAGO:0007131reciprocal meiotic recombination
BPTASGO:0007131reciprocal meiotic recombination
BPTASGO:0007596blood coagulation
BPIMPGO:0010971positive regulation of G2/M transition of mitotic cell cycle
CCIBAGO:0005657replication fork
CCIDAGO:0005657replication fork
CCIBAGO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex
CCIDAGO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex
MFIDAGO:0000400four-way junction DNA binding
MFTASGO:0003677DNA binding
MFIDAGO:0003690double-stranded DNA binding
MFIDAGO:0003697single-stranded DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008094DNA-dependent ATPase activity

Gene expression in normal tissue: RAD51B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAD51B

DatabasePathway IDPathway Des.
kegghsa03440Homologous recombination - Homo sapiens (human)
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693537Resolution of D-Loop Structures
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693568Resolution of D-loop Structures through Holliday Junction Intermediates
reactomeR-HSA-5693579Homologous DNA Pairing and Strand Exchange
reactomeR-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchange
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAD51B