RAD51B
Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameRAD51 paralog B OMIM IDMIM:602948 Ensembl IDEnsembl:ENSG00000182185 HGNC IDHGNC:HGNC:9822 PHARMGKB IDPA34178 Map Location14q24.1 | |||||
GO terms in RAD51B
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000707 | meiotic DNA recombinase assembly |
| BP | IMP | GO:0000724 | double-strand break repair via homologous recombination |
| BP | TAS | GO:0006281 | DNA repair |
| BP | TAS | GO:0006310 | DNA recombination |
| BP | IBA | GO:0007131 | reciprocal meiotic recombination |
| BP | TAS | GO:0007131 | reciprocal meiotic recombination |
Gene expression in normal tissue: RAD51B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAD51B
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAD51B
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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