RAP1GAP


Summary: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RAP1 GTPase activating proteinMIM:600278Ensembl:ENSG00000076864HGNC:HGNC:9858PA342201p36.12

GO terms in RAP1GAP


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000139Golgi membrane
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0016020membrane
BPNASGO:0007165signal transduction
BPTASGO:0007411axon guidance
BPIDAGO:0043087regulation of GTPase activity
BPIDAGO:0043547positive regulation of GTPase activity
BPIEAGO:0051056regulation of small GTPase mediated signal transduction
BPIMPGO:1903697negative regulation of microvillus assembly
MFNASGO:0003924GTPase activity
MFEXPGO:0005096GTPase activator activity
MFIDAGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIPIGO:0017016Ras GTPase binding
MFIPIGO:0042803protein homodimerization activity

Gene expression in normal tissue: RAP1GAP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAP1GAP


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392517Rap1 signalling
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-8853659RET signaling
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47201

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAP1GAP

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