RXRG
Summary: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:180247 Ensembl IDEnsembl:ENSG00000143171 HGNC IDHGNC:HGNC:10479 PHARMGKB IDPA34892 Map Location1q23.3 | |||||
GO terms in RXRG
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005654 | nucleoplasm |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IEA | GO:0048384 | retinoic acid receptor signaling pathway |
| BP | IEA | GO:0051289 | protein homotetramerization |
| BP | IEA | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
Gene expression in normal tissue: RXRG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RXRG
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP3942 | PPAR signaling pathway |
| wikipathways | WP716 | Vitamin A and Carotenoid Metabolism |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD536 | PLX-4720 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RXRG
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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