KIF13A
Summary: This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kinesin family member 13A | MIM:605433 | Ensembl:ENSG00000137177 | HGNC:HGNC:14566 | PA30098 | 6p22.3 |
GO terms in KIF13A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003777 | microtubule motor activity |
| MF | ISS | GO:0003777 | microtubule motor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IBA | GO:0016887 | ATPase activity |
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IMP | GO:0006886 | intracellular protein transport |
| BP | IBA | GO:0007018 | microtubule-based movement |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IMP | GO:0008333 | endosome to lysosome transport |
| BP | IMP | GO:0032438 | melanosome organization |
| BP | IMP | GO:0032465 | regulation of cytokinesis |
| BP | IMP | GO:0035459 | cargo loading into vesicle |
| BP | ISS | GO:0043001 | Golgi to plasma membrane protein transport |
| BP | IEA | GO:0051301 | cell division |
| BP | ISS | GO:0072383 | plus-end-directed vesicle transport along microtubule |
| CC | IDA | GO:0005813 | centrosome |
| CC | IBA | GO:0005871 | kinesin complex |
| CC | IBA | GO:0005874 | microtubule |
| CC | IEA | GO:0005874 | microtubule |
| CC | IDA | GO:0010008 | endosome membrane |
| CC | IDA | GO:0030496 | midbody |
| CC | ISS | GO:0032588 | trans-Golgi network membrane |
Gene expression in normal tissue: KIF13A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KIF13A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KIF13A
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