TBX3


Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:601621
PHARMGKB IDPA36365
Map Location12q24.21

GO terms in TBX3


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF ISS GO:0001085 RNA polymerase II transcription factor binding
Showing 1 to 6 of 50 rows rows per page

Gene expression in normal tissue: TBX3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Chromatin histone acetylation1PI3K/MTOR signaling1

Pathways in TBX3


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP2857 Mesodermal Commitment Pathway
wikipathways WP3527 Preimplantation Embryo
kegg hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
Showing 1 to 3 of 3 rows

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD507 GSK690693 1
iGMDRD328 AR-42 1
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TBX3

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​