XRCC1

Summary: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameX-ray repair cross complementing 1
OMIM IDMIM:194360
Ensembl IDEnsembl:ENSG00000073050
HGNC IDHGNC:HGNC:12828
PHARMGKB IDPA369
Map Location19q13.31

Gene Categories:

DRUG RESISTANCEDNA REPAIR

GO terms in XRCC1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0003909 DNA ligase activity
MF IPI GO:0005515 protein binding
MF IPI GO:0019899 enzyme binding
MF IMP GO:0032356 oxidized DNA binding
MF IEA GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity
CC IEA GO:0000784 nuclear chromosome, telomeric region
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Gene expression in normal tissue: XRCC1

Gene-model tissue-cancer distribution: Bubble Plot

SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 3CERVItissue: CERVI cancer: CERVIX model num: 0CERVIXtissue: CERVIX cancer: Cervical Cancer model num: 2

Gene-drug pathway distribution

Mitosis2undefined1DNA replication1Apoptosis regulation1Purine metabolism1

Pathways in XRCC1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway
reactome R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
reactome R-HSA-5685939 HDR through MMEJ (alt-NHEJ)
reactome R-HSA-5693532 DNA Double-Strand Break Repair
reactome R-HSA-5693538 Homology Directed Repair
reactome R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD79 Gemcitabine 1
iGMDRD441 TW 37 1
iGMDRD160 Cis-Platin 1
iGMDRD288 Carboplatin 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XRCC1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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