XRCC5
Summary: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:194364 Ensembl IDEnsembl:ENSG00000079246 HGNC IDHGNC:HGNC:12833 PHARMGKB IDPA37425 Map Location2q35 |
GO terms in XRCC5
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | TAS | GO:0000783 | nuclear telomere cap complex |
CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
CC | IBA | GO:0000784 | nuclear chromosome, telomeric region |
CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
CC | TAS | GO:0005576 | extracellular region |
CC | IDA | GO:0005634 | nucleus |
Gene expression in normal tissue: XRCC5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XRCC5
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-162587 | HIV Life Cycle |
reactome | R-HSA-162592 | Integration of provirus |
reactome | R-HSA-162594 | Early Phase of HIV Life Cycle |
reactome | R-HSA-162906 | HIV Infection |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-164843 | 2-LTR circle formation |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD372 | TGX 221 | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in XRCC5
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |