XRCC5
Summary: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| X-ray repair cross complementing 5 | MIM:194364 | Ensembl:ENSG00000079246 | HGNC:HGNC:12833 | PA37425 | 2q35 |
GO terms in XRCC5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000783 | nuclear telomere cap complex |
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IBA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0032993 | protein-DNA complex |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | IBA | GO:0043564 | Ku70:Ku80 complex |
| CC | IDA | GO:0043564 | Ku70:Ku80 complex |
| CC | TAS | GO:0043564 | Ku70:Ku80 complex |
| CC | IDA | GO:0070419 | nonhomologous end joining complex |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| BP | IBA | GO:0000723 | telomere maintenance |
| BP | IEA | GO:0000723 | telomere maintenance |
| BP | IDA | GO:0002218 | activation of innate immune response |
| BP | IMP | GO:0006302 | double-strand break repair |
| BP | IBA | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | IDA | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | IMP | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | TAS | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | IEA | GO:0006310 | DNA recombination |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | TAS | GO:0032204 | regulation of telomere maintenance |
| BP | IMP | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| BP | TAS | GO:0032481 | positive regulation of type I interferon production |
| BP | IEA | GO:0032508 | DNA duplex unwinding |
| BP | IEA | GO:0042493 | response to drug |
| BP | TAS | GO:0043085 | positive regulation of catalytic activity |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IDA | GO:0045860 | positive regulation of protein kinase activity |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0048660 | regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0050769 | positive regulation of neurogenesis |
| BP | TAS | GO:0051973 | positive regulation of telomerase activity |
| BP | IEA | GO:0060218 | hematopoietic stem cell differentiation |
| BP | TAS | GO:0070198 | protein localization to chromosome, telomeric region |
| BP | IEA | GO:0071398 | cellular response to fatty acid |
| BP | IEA | GO:0071475 | cellular hyperosmotic salinity response |
| BP | IBA | GO:0071480 | cellular response to gamma radiation |
| BP | IDA | GO:0071480 | cellular response to gamma radiation |
| BP | IBA | GO:0071481 | cellular response to X-ray |
| BP | IEA | GO:0071481 | cellular response to X-ray |
| BP | TAS | GO:0075713 | establishment of integrated proviral latency |
| BP | IMP | GO:1904430 | negative regulation of t-circle formation |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| MF | NAS | GO:0003677 | DNA binding |
| MF | IEA | GO:0003684 | damaged DNA binding |
| MF | IBA | GO:0003690 | double-stranded DNA binding |
| MF | TAS | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003691 | double-stranded telomeric DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | TAS | GO:0008047 | enzyme activator activity |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IBA | GO:0042162 | telomeric DNA binding |
| MF | IDA | GO:0042162 | telomeric DNA binding |
| MF | TAS | GO:0042162 | telomeric DNA binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IPI | GO:0044877 | protein-containing complex binding |
| MF | IMP | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity |
Gene expression in normal tissue: XRCC5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XRCC5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162592 | Integration of provirus |
| reactome | R-HSA-162594 | Early Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-164843 | 2-LTR circle formation |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1834941 | STING mediated induction of host immune responses |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-3270619 | IRF3-mediated induction of type I IFN |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-73894 | DNA Repair |
| biocarta | telpathway | telomeres telomerase cellular aging and immortality |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | bard1pathway | BARD1 signaling events |
| pid | dnapk_pathway | DNA-PK pathway in nonhomologous end joining |
| pid | telomerasepathway | Regulation of Telomerase |
| kegg | hsa03450 | Non-homologous end-joining - Homo sapiens (human) |
| wikipathways | WP438 | Non-homologous end joining |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in XRCC5
CLASSFICATION
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