XRCC5


Summary: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in XRCC5


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0000783 nuclear telomere cap complex
CC HDA GO:0000784 nuclear chromosome, telomeric region
CC IBA GO:0000784 nuclear chromosome, telomeric region
CC IDA GO:0000784 nuclear chromosome, telomeric region
CC TAS GO:0005576 extracellular region
CC IDA GO:0005634 nucleus
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Gene expression in normal tissue: XRCC5

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 1

Gene-drug pathway distribution

PI3K/MTOR signaling1

Pathways in XRCC5


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162587 HIV Life Cycle
reactome R-HSA-162592 Integration of provirus
reactome R-HSA-162594 Early Phase of HIV Life Cycle
reactome R-HSA-162906 HIV Infection
reactome R-HSA-1643685 Disease
reactome R-HSA-164843 2-LTR circle formation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD372 TGX 221 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XRCC5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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