SLC25A22
Summary: This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 25 member 22 | MIM:609302 | Ensembl:ENSG00000177542 | HGNC:HGNC:19954 | PA134955826 | 11p15.5 |
GO terms in SLC25A22
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006811 | ion transport |
| BP | IBA | GO:0015810 | aspartate transmembrane transport |
| BP | IDA | GO:0015813 | L-glutamate transmembrane transport |
| BP | IBA | GO:0043490 | malate-aspartate shuttle |
| BP | IEA | GO:1902600 | proton transmembrane transport |
| CC | IDA | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| MF | TAS | GO:0005280 | amino acid:proton symporter activity |
| MF | IBA | GO:0005313 | L-glutamate transmembrane transporter activity |
| MF | IDA | GO:0005313 | L-glutamate transmembrane transporter activity |
| MF | IBA | GO:0015183 | L-aspartate transmembrane transporter activity |
Gene expression in normal tissue: SLC25A22
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC25A22
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-428643 | Organic anion transporters |
| biocarta | rhodopsinpathway | visual signal transduction |
| smpdb | SMP00127 | Glucose-Alanine Cycle |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC25A22
CLASSFICATION
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