SLC25A22


Summary: This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
solute carrier family 25 member 22MIM:609302Ensembl:ENSG00000177542HGNC:HGNC:19954PA13495582611p15.5

GO terms in SLC25A22


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006811ion transport
BPIBAGO:0015810aspartate transmembrane transport
BPIDAGO:0015813L-glutamate transmembrane transport
BPIBAGO:0043490malate-aspartate shuttle
BPIEAGO:1902600proton transmembrane transport
CCIDAGO:0005743mitochondrial inner membrane
CCTASGO:0005743mitochondrial inner membrane
MFTASGO:0005280amino acid:proton symporter activity
MFIBAGO:0005313L-glutamate transmembrane transporter activity
MFIDAGO:0005313L-glutamate transmembrane transporter activity
MFIBAGO:0015183L-aspartate transmembrane transporter activity

Gene expression in normal tissue: SLC25A22

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC25A22


DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptides
reactomeR-HSA-425407SLC-mediated transmembrane transport
reactomeR-HSA-428643Organic anion transporters
biocartarhodopsinpathwayvisual signal transduction
smpdbSMP00127Glucose-Alanine Cycle
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD409Saracatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC25A22

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