SLC25A22
Summary: This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609302 Ensembl IDEnsembl:ENSG00000177542 HGNC IDHGNC:HGNC:19954 PHARMGKB IDPA134955826 Map Location11p15.5 | |||||
GO terms in SLC25A22
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006811 | ion transport |
| BP | IBA | GO:0015810 | aspartate transmembrane transport |
| BP | IDA | GO:0015813 | L-glutamate transmembrane transport |
| BP | IBA | GO:0043490 | malate-aspartate shuttle |
| BP | IEA | GO:1902600 | proton transmembrane transport |
| CC | IDA | GO:0005743 | mitochondrial inner membrane |
Gene expression in normal tissue: SLC25A22
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC25A22
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-428643 | Organic anion transporters |
| biocarta | rhodopsinpathway | visual signal transduction |
| smpdb | SMP00127 | Glucose-Alanine Cycle |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD409 | Saracatinib | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC25A22
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.