EDEM3
Summary: Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:610214 Ensembl IDEnsembl:ENSG00000116406 HGNC IDHGNC:HGNC:16787 PHARMGKB IDPA38186 Map Location1q25.3 | |||||
GO terms in EDEM3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006486 | protein glycosylation |
| BP | IMP | GO:1904382 | mannose trimming involved in glycoprotein ERAD pathway |
| BP | TAS | GO:1904382 | mannose trimming involved in glycoprotein ERAD pathway |
| CC | IEA | GO:0005788 | endoplasmic reticulum lumen |
| CC | IEA | GO:0016020 | membrane |
| CC | TAS | GO:0044322 | endoplasmic reticulum quality control compartment |
Gene expression in normal tissue: EDEM3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EDEM3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-901032 | ER Quality Control Compartment (ERQC) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD409 | Saracatinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EDEM3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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