AKR1E2
Summary: The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aldo-keto reductase family 1 member E2 | MIM:617451 | Ensembl:ENSG00000165568 | HGNC:HGNC:23437 | PA165548224 | 10p15.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in AKR1E2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| BP | IDA | GO:0055114 | oxidation-reduction process |
| MF | IBA | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity |
| MF | IBA | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| MF | IBA | GO:0016491 | oxidoreductase activity |
| MF | IDA | GO:0016491 | oxidoreductase activity |
| MF | IEA | GO:0050571 | 1,5-anhydro-D-fructose reductase activity |
Gene expression in normal tissue: AKR1E2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKR1E2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKR1E2
CLASSFICATION
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