AKR1E2

Summary: The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namealdo-keto reductase family 1 member E2
OMIM IDMIM:617451
Ensembl IDEnsembl:ENSG00000165568
HGNC IDHGNC:HGNC:23437
PHARMGKB IDPA165548224
Map Location10p15.1

Gene Categories:

DRUGGABLE GENOME

GO terms in AKR1E2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005654 nucleoplasm
CC IDA GO:0005794 Golgi apparatus
CC IBA GO:0005829 cytosol
CC IDA GO:0005829 cytosol
BP IDA GO:0055114 oxidation-reduction process
MF IBA GO:0004032 alditol:NADP+ 1-oxidoreductase activity
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Gene expression in normal tissue: AKR1E2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Metabolic pathways1ERK MAPK signaling1

Pathways in AKR1E2


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD536 PLX-4720 1
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKR1E2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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