BCL2L12
Summary: This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 like 12 | MIM:610837 | Ensembl:ENSG00000126453 | HGNC:HGNC:13787 | PA25306 | 19q13.33 |
Gene Categories:
PROTEASEGO terms in BCL2L12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0002039 | p53 binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | HDA | GO:0016020 | membrane |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| BP | IDA | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:2000773 | negative regulation of cellular senescence |
Gene expression in normal tissue: BCL2L12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL2L12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3872 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL2L12
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