PIK3R3
Summary: Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606076 Ensembl IDEnsembl:ENSG00000117461 HGNC IDHGNC:HGNC:8981 PHARMGKB IDPA33314 Map Location1p34.1 | |||||
GO terms in PIK3R3
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0008286 | insulin receptor signaling pathway |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IBA | GO:0043551 | regulation of phosphatidylinositol 3-kinase activity |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | ISS | GO:2001275 | positive regulation of glucose import in response to insulin stimulus |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: PIK3R3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3R3
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD605 | AZD6482 | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3R3
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.