VAMP4
Summary: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| vesicle associated membrane protein 4 | MIM:606909 | Ensembl:ENSG00000117533 | HGNC:HGNC:12645 | PA37269 | 1q24.3 |
Gene Categories:
CELL SURFACEGO terms in VAMP4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005764 | lysosome |
| CC | TAS | GO:0005768 | endosome |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | TAS | GO:0030133 | transport vesicle |
| CC | IEA | GO:0030285 | integral component of synaptic vesicle membrane |
| CC | TAS | GO:0030665 | clathrin-coated vesicle membrane |
| CC | TAS | GO:0032588 | trans-Golgi network membrane |
| BP | IMP | GO:0000226 | microtubule cytoskeleton organization |
| BP | IMP | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IDA | GO:0035493 | SNARE complex assembly |
| BP | IMP | GO:0043001 | Golgi to plasma membrane protein transport |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IMP | GO:0090161 | Golgi ribbon formation |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: VAMP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VAMP4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| kegg | hsa04130 | SNARE interactions in vesicular transport - Homo sapiens (human) |
| pharmgkb | PA162355621 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VAMP4
CLASSFICATION
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