DOK2
Summary: The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| docking protein 2 | MIM:604997 | Ensembl:ENSG00000147443 | HGNC:HGNC:2991 | PA27457 | 8p21.3 |
GO terms in DOK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IEA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IEA | GO:0007265 | Ras protein signal transduction |
| BP | TAS | GO:0007411 | axon guidance |
| BP | TAS | GO:0050900 | leukocyte migration |
| MF | IEA | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: DOK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DOK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-8853659 | RET signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_TCR | TCR |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DOK2
CLASSFICATION
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