DIRAS3
Summary: This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DIRAS family GTPase 3 | MIM:605193 | Ensembl:ENSG00000162595 | HGNC:HGNC:687 | PA24980 | 1p31.3 |
GO terms in DIRAS3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | TAS | GO:0006349 | regulation of gene expression by genetic imprinting |
| BP | TAS | GO:0007264 | small GTPase mediated signal transduction |
| CC | IEA | GO:0005622 | intracellular |
| CC | IEA | GO:0005886 | plasma membrane |
Gene expression in normal tissue: DIRAS3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DIRAS3
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD542 | Erismodegib | 1 |
| iGMDRD1037 | X1S.3R.RSL.3 | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD158 | NSC141540 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DIRAS3
CLASSFICATION
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