GGTLC2
Summary: This gene encodes a protein related to enzymes that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides. Unlike similar proteins, the encoded protein contains only the light chain portion and may not have catalytic activity. Alternative splicing results in multiple transcript variants. There are several related family members and related pseudogene for this gene situated in the same region of chromosome 22. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| gamma-glutamyltransferase light chain 2 | MIM:612339 | Ensembl:ENSG00000100121 | HGNC:HGNC:18596 | PA162389523 | 22q11.22 |
GO terms in GGTLC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006508 | proteolysis |
| BP | IEA | GO:0006751 | glutathione catabolic process |
| BP | ND | GO:0008150 | biological_process |
| BP | ISS | GO:1901750 | leukotriene D4 biosynthetic process |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | ND | GO:0003674 | molecular_function |
| MF | IEA | GO:0036374 | glutathione hydrolase activity |
Gene expression in normal tissue: GGTLC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GGTLC2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GGTLC2
CLASSFICATION
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