DGKI
Summary: This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| diacylglycerol kinase iota | MIM:604072 | Ensembl:ENSG00000157680 | HGNC:HGNC:2855 | PA27316 | 7q33 |
Gene Categories:
KINASEGO terms in DGKI
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007269 | neurotransmitter secretion |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0034260 | negative regulation of GTPase activity |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0046579 | positive regulation of Ras protein signal transduction |
| BP | IDA | GO:0046834 | lipid phosphorylation |
| BP | IEA | GO:0046959 | habituation |
| BP | IEA | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | IEA | GO:1900452 | regulation of long term synaptic depression |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0008021 | synaptic vesicle |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0032045 | guanyl-nucleotide exchange factor complex |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IDA | GO:0043197 | dendritic spine |
| CC | IEA | GO:0043679 | axon terminus |
| CC | IDA | GO:0045202 | synapse |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0048786 | presynaptic active zone |
| CC | IEA | GO:0060076 | excitatory synapse |
| CC | IEA | GO:0097060 | synaptic membrane |
| MF | IEA | GO:0003951 | NAD+ kinase activity |
| MF | IDA | GO:0004143 | diacylglycerol kinase activity |
| MF | TAS | GO:0004143 | diacylglycerol kinase activity |
| MF | IEA | GO:0005095 | GTPase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0017016 | Ras GTPase binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: DGKI
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DGKI
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DGKI
CLASSFICATION
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