GRAP2
Summary: This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604518 Ensembl IDEnsembl:ENSG00000100351 HGNC IDHGNC:HGNC:4563 PHARMGKB IDPA28959 Map Location22q13.1 | |||||
GO terms in GRAP2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005768 | endosome |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0007265 | Ras protein signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
Gene expression in normal tissue: GRAP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRAP2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD63 | Camptothecin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRAP2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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