CAMK2N2


Summary: This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
calcium/calmodulin dependent protein kinase II inhibitor 2MIM:608721Ensembl:ENSG00000163888HGNC:HGNC:24197PA1426722103q27.1

Gene Categories:

TYROSINE KINASEKINASE

GO terms in CAMK2N2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0008427calcium-dependent protein kinase inhibitor activity
MFIEAGO:0019901protein kinase binding
BPIEAGO:0006469negative regulation of protein kinase activity
CCIDAGO:0005634nucleus
CCIDAGO:0005813centrosome
CCIEAGO:0005829cytosol

Gene expression in normal tissue: CAMK2N2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CAMK2N2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD409Saracatinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAMK2N2

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