Summary: The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011].

CD80 moleculeMIM:112203Ensembl:ENSG00000121594HGNC:HGNC:1700PA262393q13.33

GO terms in CD80

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFIPIGO:0005515protein binding
MFNASGO:0015026coreceptor activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
BPIBAGO:0006955immune response
BPIBAGO:0007165signal transduction
BPIBAGO:0007166cell surface receptor signaling pathway
BPNASGO:0009967positive regulation of signal transduction
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0031295T cell costimulation
BPTASGO:0031295T cell costimulation
BPNASGO:0035556intracellular signal transduction
BPIBAGO:0042102positive regulation of T cell proliferation
BPIBAGO:0042130negative regulation of T cell proliferation
BPNASGO:0045086positive regulation of interleukin-2 biosynthetic process
BPNASGO:0045425positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
BPNASGO:0045627positive regulation of T-helper 1 cell differentiation
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0046718viral entry into host cell
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIBAGO:0071222cellular response to lipopolysaccharide
CCTASGO:0005886plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCHDAGO:0009986cell surface
CCIBAGO:0009986cell surface
CCIEAGO:0016021integral component of membrane
CCIDAGO:0098636protein complex involved in cell adhesion

Gene expression in normal tissue: CD80

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD80

DatabasePathway IDPathway Des.
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04672Intestinal immune network for IgA production - Homo sapiens (human)
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05330Allograft rejection - Homo sapiens (human)
kegghsa05332Graft-versus-host disease - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP4141PI3K-AKT-mTOR - VitD3 Signalling
wikipathwaysWP453Inflammatory Response Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389357CD28 dependent PI3K/Akt signaling
reactomeR-HSA-389359CD28 dependent Vav1 pathway
reactomeR-HSA-389513CTLA4 inhibitory signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
biocartactla4pathwaythe co-stimulatory signal during t-cell activation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD80