CD80
Summary: The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameCD80 molecule OMIM IDMIM:112203 Ensembl IDEnsembl:ENSG00000121594 HGNC IDHGNC:HGNC:1700 PHARMGKB IDPA26239 Map Location3q13.33 | |||||
GO terms in CD80
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0015026 | coreceptor activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| BP | IBA | GO:0006955 | immune response |
| BP | IBA | GO:0007165 | signal transduction |
Gene expression in normal tissue: CD80
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD80
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD491 | TAE-684 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD80
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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