GOSR2
Summary: This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| golgi SNAP receptor complex member 2 | MIM:604027 | Ensembl:ENSG00000108433 | HGNC:HGNC:4431 | PA28816 | 17q21.32 |
GO terms in GOSR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0005829 | cytosol |
| CC | IBA | GO:0012507 | ER to Golgi transport vesicle membrane |
| CC | TAS | GO:0012507 | ER to Golgi transport vesicle membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0031201 | SNARE complex |
| CC | ISS | GO:0031201 | SNARE complex |
| CC | IBA | GO:0031902 | late endosome membrane |
| CC | TAS | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| BP | IBA | GO:0006623 | protein targeting to vacuole |
| BP | IBA | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IDA | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IBA | GO:0006891 | intra-Golgi vesicle-mediated transport |
| BP | IDA | GO:0006891 | intra-Golgi vesicle-mediated transport |
| BP | IBA | GO:0006896 | Golgi to vacuole transport |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | IBA | GO:0042147 | retrograde transport, endosome to Golgi |
| BP | TAS | GO:0048208 | COPII vesicle coating |
| BP | IBA | GO:0048280 | vesicle fusion with Golgi apparatus |
| MF | IBA | GO:0000149 | SNARE binding |
| MF | IBA | GO:0005484 | SNAP receptor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: GOSR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GOSR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-204005 | COPII-mediated vesicle transport |
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5694530 | Cargo concentration in the ER |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807878 | COPI-mediated anterograde transport |
| reactome | R-HSA-6811438 | Intra-Golgi traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| wikipathways | WP3472 | XBP1(S) activates chaperone genes |
| kegg | hsa04130 | SNARE interactions in vesicular transport - Homo sapiens (human) |
| pid | arf_3pathway | Arf1 pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GOSR2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.