KEAP1


Summary: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
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GO terms in KEAP1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IBA GO:0008134 transcription factor binding
MF IPI GO:0008134 transcription factor binding
MF IEA GO:0042803 protein homodimerization activity
MF IEA GO:0097718 disordered domain specific binding
CC IDA GO:0005654 nucleoplasm
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Gene expression in normal tissue: KEAP1

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 4

Gene-drug pathway distribution

WNT signaling1JNK and p38 signaling1undefined1Other, kinases1

Pathways in KEAP1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-5688426 Deubiquitination
reactome R-HSA-5689880 Ub-specific processing proteases
reactome R-HSA-597592 Post-translational protein modification
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD588 HG-5-88-01 1
iGMDRD232 FTI-277 1
iGMDRD396 AS601245 1
iGMDRD218 XAV 939 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KEAP1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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