ACTC1


Summary: Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
actin, alpha, cardiac muscle 1MIM:102540Ensembl:ENSG00000159251HGNC:HGNC:143PA16237557115q14

Gene Categories:

DRUG RESISTANCE

GO terms in ACTC1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005524ATP binding
MFIDAGO:0016887ATPase activity
MFIDAGO:0017022myosin binding
MFIPIGO:0017022myosin binding
BPISSGO:0010628positive regulation of gene expression
BPIDAGO:0030048actin filament-based movement
BPTASGO:0030049muscle filament sliding
BPISSGO:0030240skeletal muscle thin filament assembly
BPISSGO:0031032actomyosin structure organization
BPIMPGO:0033275actin-myosin filament sliding
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0045471response to ethanol
BPISSGO:0055003cardiac myofibril assembly
BPISSGO:0055008cardiac muscle tissue morphogenesis
BPIMPGO:0060047heart contraction
BPIEAGO:0060048cardiac muscle contraction
BPISSGO:0090131mesenchyme migration
CCHDAGO:0005615extracellular space
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005884actin filament
CCHDAGO:0005925focal adhesion
CCHDAGO:0016020membrane
CCIDAGO:0030017sarcomere
CCISSGO:0030027lamellipodium
CCISSGO:0030175filopodium
CCISSGO:0031674I band
CCIDAGO:0042643actomyosin, actin portion
CCISSGO:0044297cell body
CCHDAGO:0070062extracellular exosome
CCHDAGO:0072562blood microparticle

Gene expression in normal tissue: ACTC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACTC1


DatabasePathway IDPathway Des.
reactomeR-HSA-390522Striated Muscle Contraction
reactomeR-HSA-397014Muscle contraction
kegghsa04260Cardiac muscle contraction - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP383Striated Muscle Contraction

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACTC1

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