ADCY2
Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adenylate cyclase 2 | MIM:103071 | Ensembl:ENSG00000078295 | HGNC:HGNC:233 | PA24561 | 5p15.31 |
GO terms in ADCY2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | ISS | GO:0004016 | adenylate cyclase activity |
| MF | NAS | GO:0004016 | adenylate cyclase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0008179 | adenylate cyclase binding |
| MF | ISS | GO:0030145 | manganese ion binding |
| MF | ISS | GO:0046982 | protein heterodimerization activity |
| BP | TAS | GO:0003091 | renal water homeostasis |
| BP | ISS | GO:0006171 | cAMP biosynthetic process |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | ISS | GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway |
| BP | ISS | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| BP | ISS | GO:0019933 | cAMP-mediated signaling |
| BP | TAS | GO:0071377 | cellular response to glucagon stimulus |
| BP | ISS | GO:1904322 | cellular response to forskolin |
| CC | ISS | GO:0005622 | intracellular |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0016020 | membrane |
| CC | ISS | GO:0030425 | dendrite |
| CC | ISS | GO:0045121 | membrane raft |
Gene expression in normal tissue: ADCY2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADCY2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111931 | PKA-mediated phosphorylation of CREB |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163359 | Glucagon signaling in metabolic regulation |
| reactome | R-HSA-163615 | PKA activation |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-164378 | PKA activation in glucagon signalling |
| reactome | R-HSA-170660 | Adenylate cyclase activating pathway |
| reactome | R-HSA-170670 | Adenylate cyclase inhibitory pathway |
| reactome | R-HSA-170670 | Adenylate cyclase inhibitory pathway |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| reactome | R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins |
| reactome | R-HSA-445717 | Aquaporin-mediated transport |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-977443 | GABA receptor activation |
| reactome | R-HSA-977443 | GABA receptor activation |
| reactome | R-HSA-977444 | GABA B receptor activation |
| reactome | R-HSA-977444 | GABA B receptor activation |
| reactome | R-HSA-991365 | Activation of GABAB receptors |
| reactome | R-HSA-991365 | Activation of GABAB receptors |
| reactome | R-HSA-997269 | Inhibition of adenylate cyclase pathway |
| reactome | R-HSA-997269 | Inhibition of adenylate cyclase pathway |
| wikipathways | WP1602 | Nicotine Activity on Dopaminergic Neurons |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP4222 | Phosphodiesterases in neuronal function |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| smpdb | SMP00308 | Dopamine Activation of Neurological Reward System |
| smpdb | SMP00309 | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin |
| smpdb | SMP00310 | Corticotropin Activation of Cortisol Production |
| smpdb | SMP00311 | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin |
| smpdb | SMP00312 | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| smpdb | SMP00322 | Vasopressin Regulation of Water Homeostasis |
| smpdb | SMP00333 | Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone |
| smpdb | SMP00335 | Intracellular Signalling Through Histamine H2 Receptor and Histamine |
| smpdb | SMP00338 | Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin |
| smpdb | SMP00343 | Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 |
| smpdb | SMP00354 | Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| pid | endothelinpathway | Endothelins |
| pid | lpa4_pathway | LPA4-mediated signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA161749006 | Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA162355621 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADCY2
CLASSFICATION
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