ADNP


Summary: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
activity dependent neuroprotector homeoboxMIM:611386Ensembl:ENSG00000101126HGNC:HGNC:15766PA2458220q13.13

Gene Categories:

KINASE

GO terms in ADNP


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIEAGO:0003682chromatin binding
MFIEAGO:0005507copper ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0042277peptide binding
MFIEAGO:0048487beta-tubulin binding
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0007614short-term memory
BPIEAGO:0009743response to carbohydrate
BPIEAGO:0010035response to inorganic substance
BPIEAGO:0010629negative regulation of gene expression
BPIEAGO:0010835regulation of protein ADP-ribosylation
BPIEAGO:0031668cellular response to extracellular stimulus
BPIEAGO:0032091negative regulation of protein binding
BPIEAGO:0032147activation of protein kinase activity
BPIEAGO:0033484nitric oxide homeostasis
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0044849estrous cycle
BPIEAGO:0045773positive regulation of axon extension
BPIEAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0050805negative regulation of synaptic transmission
BPIEAGO:0051965positive regulation of synapse assembly
CCIEAGO:0005615extracellular space
CCIEAGO:0005634nucleus
CCIEAGO:0005737cytoplasm
CCIEAGO:0030424axon
CCIEAGO:0030425dendrite
CCIEAGO:0043025neuronal cell body

Gene expression in normal tissue: ADNP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADNP


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADNP

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