AGPAT4


Summary: This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
1-acylglycerol-3-phosphate O-acyltransferase 4MIM:614795Ensembl:ENSG00000026652HGNC:HGNC:20885PA1349610476q26

GO terms in AGPAT4


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:00038411-acylglycerol-3-phosphate O-acyltransferase activity
MFNASGO:00038411-acylglycerol-3-phosphate O-acyltransferase activity
MFTASGO:00038411-acylglycerol-3-phosphate O-acyltransferase activity
MFIPIGO:0005515protein binding
MFIBAGO:0016746transferase activity, transferring acyl groups
BPIBAGO:0006644phospholipid metabolic process
BPTASGO:0006654phosphatidic acid biosynthetic process
BPNASGO:0008654phospholipid biosynthetic process
BPIEAGO:0016024CDP-diacylglycerol biosynthetic process
CCIBAGO:0005741mitochondrial outer membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCIBAGO:0012505endomembrane system
CCIEAGO:0016021integral component of membrane

Gene expression in normal tissue: AGPAT4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AGPAT4


DatabasePathway IDPathway Des.
wikipathwaysWP325Triacylglyceride Synthesis
kegghsa00561Glycerolipid metabolism - Homo sapiens (human)
kegghsa00564Glycerophospholipid metabolism - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
humancycPWY-5667CDP-diacylglycerol biosynthesis
humancycTRIGLSYN-PWYtriacylglycerol biosynthesis
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483166Synthesis of PA
reactomeR-HSA-1483206Glycerophospholipid biosynthesis
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD491TAE-6841

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AGPAT4

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