AGR2


Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
anterior gradient 2, protein disulphide isomerase family memberMIM:606358Ensembl:ENSG00000106541HGNC:HGNC:328PA246257p21.1

Gene Categories:

DRUGGABLE GENOME

GO terms in AGR2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0002162dystroglycan binding
MFIDAGO:0002162dystroglycan binding
MFIPIGO:0005154epidermal growth factor receptor binding
MFIPIGO:0005515protein binding
MFIMPGO:0042803protein homodimerization activity
CCIDAGO:0005615extracellular space
CCIBAGO:0005783endoplasmic reticulum
CCIMPGO:0005783endoplasmic reticulum
CCISSGO:0005783endoplasmic reticulum
BPIMPGO:0010628positive regulation of gene expression
BPIMPGO:0010811positive regulation of cell-substrate adhesion
BPIBAGO:0030154cell differentiation
BPIMPGO:0034976response to endoplasmic reticulum stress
BPIMPGO:0045742positive regulation of epidermal growth factor receptor signaling pathway
BPISSGO:0048546digestive tract morphogenesis
BPISSGO:0048639positive regulation of developmental growth
BPIEAGO:0060480lung goblet cell differentiation
BPIBAGO:0060548negative regulation of cell death
BPIMPGO:0060548negative regulation of cell death
BPISSGO:0070254mucus secretion
BPIMPGO:1903078positive regulation of protein localization to plasma membrane
BPIDAGO:1903896positive regulation of IRE1-mediated unfolded protein response
BPIDAGO:1903899positive regulation of PERK-mediated unfolded protein response

Gene expression in normal tissue: AGR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AGR2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD221Tamoxifen1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AGR2

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