AGR2
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| anterior gradient 2, protein disulphide isomerase family member | MIM:606358 | Ensembl:ENSG00000106541 | HGNC:HGNC:328 | PA24625 | 7p21.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in AGR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0002162 | dystroglycan binding |
| MF | IDA | GO:0002162 | dystroglycan binding |
| MF | IPI | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0042803 | protein homodimerization activity |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IMP | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0010811 | positive regulation of cell-substrate adhesion |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IMP | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| BP | ISS | GO:0048546 | digestive tract morphogenesis |
| BP | ISS | GO:0048639 | positive regulation of developmental growth |
| BP | IEA | GO:0060480 | lung goblet cell differentiation |
| BP | IBA | GO:0060548 | negative regulation of cell death |
| BP | IMP | GO:0060548 | negative regulation of cell death |
| BP | ISS | GO:0070254 | mucus secretion |
| BP | IMP | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IDA | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response |
| BP | IDA | GO:1903899 | positive regulation of PERK-mediated unfolded protein response |
Gene expression in normal tissue: AGR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AGR2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AGR2
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