AKAP14


Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
A-kinase anchoring protein 14MIM:300462Ensembl:ENSG00000186471HGNC:HGNC:24061PA134914893Xq24

GO terms in AKAP14


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005930axoneme
CCIBAGO:0005952cAMP-dependent protein kinase complex
CCIMPGO:0005952cAMP-dependent protein kinase complex
BPNDGO:0008150biological_process
MFIPIGO:0005515protein binding
MFIBAGO:0034237protein kinase A regulatory subunit binding
MFIPIGO:0034237protein kinase A regulatory subunit binding

Gene expression in normal tissue: AKAP14

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AKAP14


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKAP14

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