AKAP14
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| A-kinase anchoring protein 14 | MIM:300462 | Ensembl:ENSG00000186471 | HGNC:HGNC:24061 | PA134914893 | Xq24 |
GO terms in AKAP14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005930 | axoneme |
| CC | IBA | GO:0005952 | cAMP-dependent protein kinase complex |
| CC | IMP | GO:0005952 | cAMP-dependent protein kinase complex |
| BP | ND | GO:0008150 | biological_process |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0034237 | protein kinase A regulatory subunit binding |
| MF | IPI | GO:0034237 | protein kinase A regulatory subunit binding |
Gene expression in normal tissue: AKAP14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKAP14
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKAP14
CLASSFICATION
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