AKT1S1


Summary: AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
AKT1 substrate 1MIM:610221Ensembl:ENSG00000204673HGNC:HGNC:28426PA13494358719q13.33

Gene Categories:

DRUGGABLE GENOMEKINASE

GO terms in AKT1S1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006469negative regulation of protein kinase activity
BPIDAGO:0006469negative regulation of protein kinase activity
BPIBAGO:0032007negative regulation of TOR signaling
BPIDAGO:0032007negative regulation of TOR signaling
BPIBAGO:0038202TORC1 signaling
BPISSGO:0042981regulation of apoptotic process
BPISSGO:0043523regulation of neuron apoptotic process
BPIDAGO:0045792negative regulation of cell size
BPIEAGO:0048011neurotrophin TRK receptor signaling pathway
BPTASGO:1900034regulation of cellular response to heat
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0031931TORC1 complex
CCIDAGO:0031931TORC1 complex
MFIPIGO:0005515protein binding

Gene expression in normal tissue: AKT1S1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AKT1S1


DatabasePathway IDPathway Des.
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-165159mTOR signalling
reactomeR-HSA-166208mTORC1-mediated signalling
reactomeR-HSA-198323AKT phosphorylates targets in the cytosol
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-3371571HSF1-dependent transactivation
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006925Intracellular signaling by second messengers
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
pidlkb1_pathwayLKB1 signaling events
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidmtor_4pathwaymTOR signaling pathway
wikipathwaysWP1471Target Of Rapamycin (TOR) Signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4011Steatosis AOP
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP615Senescence and Autophagy in Cancer

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD734AZ31461
iGMDRD711BRD-K415973741
iGMDRD452PF-5732281
iGMDRD628BRD-K551167081

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKT1S1

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