AP2M1


Summary: This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
adaptor related protein complex 2 subunit mu 1MIM:601024Ensembl:ENSG00000161203HGNC:HGNC:564PA248553q27.1

Gene Categories:

TRANSPORTER

GO terms in AP2M1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006886intracellular protein transport
BPIMPGO:0016050vesicle organization
BPTASGO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
BPIMPGO:0031623receptor internalization
BPTASGO:0032802low-density lipoprotein particle receptor catabolic process
BPTASGO:0034383low-density lipoprotein particle clearance
BPTASGO:0048013ephrin receptor signaling pathway
BPTASGO:0050690regulation of defense response to virus by virus
BPTASGO:0060071Wnt signaling pathway, planar cell polarity pathway
BPTASGO:0061024membrane organization
BPTASGO:0072583clathrin-dependent endocytosis
BPIMPGO:0097494regulation of vesicle size
BPIMPGO:1903077negative regulation of protein localization to plasma membrane
CCTASGO:0005765lysosomal membrane
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0030122AP-2 adaptor complex
CCTASGO:0030666endocytic vesicle membrane
CCTASGO:0030669clathrin-coated endocytic vesicle membrane
CCTASGO:0036020endolysosome membrane
CCNASGO:0045334clathrin-coated endocytic vesicle
CCHDAGO:0070062extracellular exosome
MFIDAGO:0005048signal sequence binding
MFTASGO:0005215transporter activity
MFIPIGO:0005515protein binding
MFIEAGO:0008289lipid binding
MFTASGO:0035615clathrin adaptor activity
MFIPIGO:0044325ion channel binding
MFISSGO:0050750low-density lipoprotein particle receptor binding

Gene expression in normal tissue: AP2M1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AP2M1


DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-157858Gap junction trafficking and regulation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-1643685Disease
reactomeR-HSA-164938Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
reactomeR-HSA-164939Nef mediated downregulation of CD28 cell surface expression
reactomeR-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesis
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167590Nef Mediated CD4 Down-regulation
reactomeR-HSA-168256Immune System
reactomeR-HSA-174824Plasma lipoprotein assembly, remodeling, and clearance
reactomeR-HSA-177504Retrograde neurotrophin signalling
reactomeR-HSA-177504Retrograde neurotrophin signalling
reactomeR-HSA-182218Nef Mediated CD8 Down-regulation
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-190828Gap junction trafficking
reactomeR-HSA-190873Gap junction degradation
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-196025Formation of annular gap junctions
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-2132295MHC class II antigen presentation
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-416993Trafficking of GluR2-containing AMPA receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-437239Recycling pathway of L1
reactomeR-HSA-437239Recycling pathway of L1
reactomeR-HSA-5099900WNT5A-dependent internalization of FZD4
reactomeR-HSA-5140745WNT5A-dependent internalization of FZD2, FZD5 and ROR2
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-8866427VLDLR internalisation and degradation
reactomeR-HSA-8964038LDL clearance
reactomeR-HSA-8964043Plasma lipoprotein clearance
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartabarrestinpathway-arrestins in gpcr desensitization
biocartandkdynaminpathwayendocytotic role of ndk phosphins and dynamin
pidarf_3pathwayArf1 pathway
netpathPathway_GhrelinGhrelin
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04721Synaptic vesicle cycle - Homo sapiens (human)
kegghsa04961Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
wikipathwaysWP2267Synaptic Vesicle Pathway
wikipathwaysWP4159GABA receptor Signaling
wikipathwaysWP437EGF-EGFR Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AP2M1

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