Summary: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017].

amyloid beta precursor protein binding family A member 2MIM:602712Ensembl:ENSG00000034053HGNC:HGNC:579PA2487015q13.1

GO terms in APBA2

Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005886plasma membrane
CCIEAGO:0005886plasma membrane
CCIEAGO:0008021synaptic vesicle
CCIBAGO:0043197dendritic spine
BPIEAGO:0001701in utero embryonic development
BPIBAGO:0007268chemical synaptic transmission
BPIEAGO:0007268chemical synaptic transmission
BPTASGO:0007399nervous system development
BPIEAGO:0007626locomotory behavior
BPIEAGO:0010468regulation of gene expression
BPIEAGO:0015031protein transport
BPIBAGO:0023051regulation of signaling
BPIEAGO:0035264multicellular organism growth
MFIBAGO:0001540amyloid-beta binding
MFIEAGO:0001540amyloid-beta binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: APBA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in APBA2

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794362Protein-protein interactions at synapses

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in APBA2