APOBEC3H


Summary: This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
apolipoprotein B mRNA editing enzyme catalytic subunit 3HMIM:610976Ensembl:ENSG00000100298HGNC:HGNC:24100PA16237669422q13.1

GO terms in APOBEC3H


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003723RNA binding
MFIBAGO:0004126cytidine deaminase activity
MFIDAGO:0004126cytidine deaminase activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
CCIDAGO:0000932P-body
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
BPIEAGO:0009972cytidine deamination
BPIDAGO:0010529negative regulation of transposition
BPIMPGO:0010529negative regulation of transposition
BPIBAGO:0016554cytidine to uridine editing
BPIEAGO:0045087innate immune response
BPIDAGO:0045869negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
BPIMPGO:0048525negative regulation of viral process
BPIDAGO:0051607defense response to virus
BPIDAGO:0070383DNA cytosine deamination
BPIBAGO:0080111DNA demethylation

Gene expression in normal tissue: APOBEC3H

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in APOBEC3H


DatabasePathway IDPathway Des.
reactomeR-HSA-72200mRNA Editing: C to U Conversion
reactomeR-HSA-75072mRNA Editing
reactomeR-HSA-75094Formation of the Editosome
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 32

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in APOBEC3H

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