ARHGAP8


Summary: This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Rho GTPase activating protein 8MIM:609405Ensembl:ENSG00000241484HGNC:HGNC:677PA2496122q13.31

GO terms in ARHGAP8


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005096GTPase activator activity
MFTASGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
CCTASGO:0005829cytosol
BPIEAGO:0007165signal transduction
BPIEAGO:0043547positive regulation of GTPase activity
BPTASGO:0051056regulation of small GTPase mediated signal transduction
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade

Gene expression in normal tissue: ARHGAP8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARHGAP8


DatabasePathway IDPathway Des.
pidrhoa_reg_pathwayRegulation of RhoA activity
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGAP8

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