ARID4B
Summary: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| AT-rich interaction domain 4B | MIM:609696 | Ensembl:ENSG00000054267 | HGNC:HGNC:15550 | PA134940494 | 1q42.3 |
Gene Categories:
HISTONE MODIFICATIONGO terms in ARID4B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ND | GO:0003674 | molecular_function |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
| BP | IEA | GO:0006349 | regulation of gene expression by genetic imprinting |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0016575 | histone deacetylation |
| BP | IEA | GO:0034773 | histone H4-K20 trimethylation |
| BP | IEA | GO:0036124 | histone H3-K9 trimethylation |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0097368 | establishment of Sertoli cell barrier |
| CC | ND | GO:0005575 | cellular_component |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: ARID4B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARID4B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARID4B
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