ATG9B
Summary: This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| autophagy related 9B | MIM:612205 | Ensembl:ENSG00000181652 | HGNC:HGNC:21899 | PA134883165 | 7q36.1 |
GO terms in ATG9B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000407 | phagophore assembly site |
| CC | IEA | GO:0000421 | autophagosome membrane |
| CC | IBA | GO:0005776 | autophagosome |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| BP | IBA | GO:0000045 | autophagosome assembly |
| BP | IDA | GO:0000045 | autophagosome assembly |
| BP | IBA | GO:0000422 | autophagy of mitochondrion |
| BP | IBA | GO:0034497 | protein localization to phagophore assembly site |
| BP | IBA | GO:0044805 | late nucleophagy |
Gene expression in normal tissue: ATG9B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATG9B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| kegg | hsa04136 | Autophagy - other - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| wikipathways | WP2509 | Nanoparticle triggered autophagic cell death |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATG9B
CLASSFICATION
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