ATL1


Summary: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
atlastin GTPase 1MIM:606439Ensembl:ENSG00000198513HGNC:HGNC:11231PA3606114q22.1

GO terms in ATL1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0007029endoplasmic reticulum organization
BPISSGO:0007409axonogenesis
BPIDAGO:0051260protein homooligomerization
BPIMPGO:1990809endoplasmic reticulum tubular network membrane organization
CCISSGO:0000137Golgi cis cisterna
CCIEAGO:0000139Golgi membrane
CCIDAGO:0005783endoplasmic reticulum
CCISSGO:0005789endoplasmic reticulum membrane
CCISSGO:0005794Golgi apparatus
CCIDAGO:0016021integral component of membrane
CCIEAGO:0030424axon
CCISSGO:0071782endoplasmic reticulum tubular network
CCIDAGO:0098826endoplasmic reticulum tubular network membrane
MFIDAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFISSGO:0005525GTP binding
MFIDAGO:0042802identical protein binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: ATL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATL1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATL1

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