Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].

ATPase phospholipid transporting 8B3MIM:605866Ensembl:ENSG00000130270HGNC:HGNC:13535PA2516819p13.3

GO terms in ATP8B3

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0002080acrosomal membrane
CCIEAGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005794Golgi apparatus
CCIBAGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
BPIBAGO:0007030Golgi organization
BPIBAGO:0045332phospholipid translocation
BPIEAGO:0045332phospholipid translocation
MFIEAGO:0000287magnesium ion binding
MFIBAGO:0004012phospholipid-translocating ATPase activity
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: ATP8B3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP8B3

DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP8B3