B4GALT3


Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
beta-1,4-galactosyltransferase 3MIM:604014Ensembl:ENSG00000158850HGNC:HGNC:926PA252251q23.3

GO terms in B4GALT3


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003831beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
MFIEAGO:0003945N-acetyllactosamine synthase activity
MFIDAGO:0008378galactosyltransferase activity
MFIEAGO:0046872metal ion binding
CCTASGO:0000139Golgi membrane
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005829cytosol
CCIEAGO:0016021integral component of membrane
CCIEAGO:0032580Golgi cisterna membrane
CCHDAGO:0070062extracellular exosome
BPIEAGO:0005975carbohydrate metabolic process
BPIEAGO:0006486protein glycosylation
BPIDAGO:0006682galactosylceramide biosynthetic process
BPTASGO:0018146keratan sulfate biosynthetic process

Gene expression in normal tissue: B4GALT3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in B4GALT3


DatabasePathway IDPathway Des.
kegghsa00510N-Glycan biosynthesis - Homo sapiens (human)
kegghsa00514Other types of O-glycan biosynthesis - Homo sapiens (human)
kegghsa00515Mannose type O-glycan biosynthesis - Homo sapiens (human)
kegghsa00533Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human)
kegghsa00601Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human)
humancycPWY-7434terminal O-glycans residues modification
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1630316Glycosaminoglycan metabolism
reactomeR-HSA-1638074Keratan sulfate/keratin metabolism
reactomeR-HSA-2022854Keratan sulfate biosynthesis
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
reactomeR-HSA-975576N-glycan antennae elongation in the medial/trans-Golgi
reactomeR-HSA-975577N-Glycan antennae elongation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD409Saracatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in B4GALT3

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