BCL2L2
Summary: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 like 2 | MIM:601931 | Ensembl:ENSG00000129473 | HGNC:HGNC:995 | PA25307 | 14q11.2 |
GO terms in BCL2L2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005741 | mitochondrial outer membrane |
| CC | IEA | GO:0005829 | cytosol |
| CC | IMP | GO:0097136 | Bcl-2 family protein complex |
| BP | TAS | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0060011 | Sertoli cell proliferation |
| BP | IBA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IBA | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0046982 | protein heterodimerization activity |
| MF | IMP | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0051400 | BH domain binding |
| MF | IPI | GO:0097718 | disordered domain specific binding |
Gene expression in normal tissue: BCL2L2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL2L2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | p53downstreampathway | Direct p53 effectors |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3872 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL2L2
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