BCOR
Summary: The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL6 corepressor | MIM:300485 | Ensembl:ENSG00000183337 | HGNC:HGNC:20893 | PA134921737 | Xp11.4 |
GO terms in BCOR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000415 | negative regulation of histone H3-K36 methylation |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0007507 | heart development |
| BP | IMP | GO:0030502 | negative regulation of bone mineralization |
| BP | IDA | GO:0035518 | histone H2A monoubiquitination |
| BP | IMP | GO:0042476 | odontogenesis |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0051572 | negative regulation of histone H3-K4 methylation |
| BP | IMP | GO:0060021 | roof of mouth development |
| BP | IMP | GO:0065001 | specification of axis polarity |
| BP | IMP | GO:0070171 | negative regulation of tooth mineralization |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0031519 | PcG protein complex |
| MF | IEA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IMP | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0031072 | heat shock protein binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IMP | GO:0044212 | transcription regulatory region DNA binding |
Gene expression in normal tissue: BCOR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCOR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD669 | PDK1 inhibitor | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD130 | Enzastaurin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCOR
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