Summary: The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010].

BCL6 corepressorMIM:300485Ensembl:ENSG00000183337HGNC:HGNC:20893PA134921737Xp11.4

GO terms in BCOR

Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPIMPGO:0000415negative regulation of histone H3-K36 methylation
BPIEAGO:0006351transcription, DNA-templated
BPIMPGO:0007507heart development
BPIMPGO:0030502negative regulation of bone mineralization
BPIDAGO:0035518histone H2A monoubiquitination
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0051572negative regulation of histone H3-K4 methylation
BPIMPGO:0060021roof of mouth development
BPIMPGO:0065001specification of axis polarity
BPIMPGO:0070171negative regulation of tooth mineralization
CCIDAGO:0031519PcG protein complex
MFIEAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0003714transcription corepressor activity
MFIMPGO:0003714transcription corepressor activity
MFIDAGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0031072heat shock protein binding
MFIPIGO:0042826histone deacetylase binding
MFIMPGO:0044212transcription regulatory region DNA binding

Gene expression in normal tissue: BCOR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCOR

DatabasePathway IDPathway Des.
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD669PDK1 inhibitor1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCOR