BRWD1


Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
bromodomain and WD repeat domain containing 1MIM:617824Ensembl:ENSG00000185658HGNC:HGNC:12760PA13490687921q22.2

GO terms in BRWD1


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
BPTASGO:0006325chromatin organization
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIBAGO:0007010cytoskeleton organization
BPIMPGO:0007010cytoskeleton organization
BPIBAGO:0008360regulation of cell shape
BPIMPGO:0008360regulation of cell shape
BPTASGO:0038111interleukin-7-mediated signaling pathway
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol

Gene expression in normal tissue: BRWD1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BRWD1


DatabasePathway IDPathway Des.
wikipathwaysWP2673Interleukin-7 signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-4839726Chromatin organization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD3615Z-7-Oxozeaenol1
iGMDRD399Selumetinib1
iGMDRD1002rTRAIL2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BRWD1

​​​​