CADPS
Summary: This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
calcium dependent secretion activator | MIM:604667 | Ensembl:ENSG00000163618 | HGNC:HGNC:1426 | PA26024 | 3p14.2 |
GO terms in CADPS
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | TAS | GO:0006887 | exocytosis |
BP | IEA | GO:0015031 | protein transport |
BP | IEA | GO:0016050 | vesicle organization |
BP | IEA | GO:0016082 | synaptic vesicle priming |
BP | IEA | GO:0050432 | catecholamine secretion |
BP | IEA | GO:0099525 | presynaptic dense core vesicle exocytosis |
CC | TAS | GO:0005829 | cytosol |
CC | IEA | GO:0030054 | cell junction |
CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
CC | IEA | GO:0098793 | presynapse |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008289 | lipid binding |
MF | ISS | GO:0019901 | protein kinase binding |
MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: CADPS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CADPS
Database | Pathway ID | Pathway Des. |
---|
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD399 | Selumetinib | 1 |
iGMDRD309 | 17AAG | 1 |
iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CADPS