CD37
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD37 molecule | MIM:151523 | Ensembl:ENSG00000104894 | HGNC:HGNC:1666 | PA26213 | 19q13.33 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CD37
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0001772 | immunological synapse |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
Gene expression in normal tissue: CD37
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD37
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| wikipathways | WP3945 | TYROBP Causal Network |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD37
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.