CDKN1C
Summary: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase inhibitor 1C | MIM:600856 | Ensembl:ENSG00000129757 | HGNC:HGNC:1786 | PA26320 | 11p15.4 |
GO terms in CDKN1C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0004860 | protein kinase inhibitor activity |
| MF | IEA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0044877 | protein-containing complex binding |
| BP | IEA | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0033673 | negative regulation of kinase activity |
| BP | IDA | GO:0042326 | negative regulation of phosphorylation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IGI | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IEA | GO:0071901 | negative regulation of protein serine/threonine kinase activity |
| BP | IMP | GO:1904030 | negative regulation of cyclin-dependent protein kinase activity |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: CDKN1C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKN1C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP2855 | Dopaminergic Neurogenesis |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP474 | Endochondral Ossification |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKN1C
CLASSFICATION
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